Calcium channel antagonists: pharmacological considerations.
نویسندگان
چکیده
منابع مشابه
Calcium-channel antagonists in cardiovascular disease.
In the last 2 years there has been considerable controversy over the safety of certain calcium antagonists. This article discusses recent drug developments, summarizes the publications that sparked the controversy, highlights results of the l latest trials of calcium antagonists and considers the range of clinical conditions in which calcium antagonists may play a useful role.
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The goal of this study was to determine the effects of the L-type calcium channel blockers verapamil and diltiazem on the currents of voltage-gated potassium channel (fKv1.4ΔN), an N-terminal-deleted mutant of the ferret Kv1.4 potassium channel. Measurements were made using a two electrode voltage clamp technique with channels expressed stably in Xenopus oocytes. The fKv1.4ΔN currents displayed...
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calcium mobilization is known to be an important factor in the activation of cells involved in inflammation,so,calcium-channel antagonists are be expected ti exhibit antiinflammatory activity.in the present study,we evaluateted the antiinflammatory effects of two calcium channel blockers,verapamil and nifedipine on adjuvant induced chronic in flammation in rat paw.sixty adult male rats were div...
متن کاملEffects of L-type Calcium Channel Antagonists Verapamil and Diltiazem on fKv1.4ΔN Currents in Xenopus oocytes
The goal of this study was to determine the effects of the L-type calcium channel blockers verapamil and diltiazem on the currents of voltage-gated potassium channel (fKv1.4ΔN), an N-terminal-deleted mutant of the ferret Kv1.4 potassium channel. Measurements were made using a two electrode voltage clamp technique with channels expressed stably in Xenopus oocytes. The fKv1.4ΔN currents displayed...
متن کاملPHARMAC responds to Stewart Mann on dihydropyridine calcium channel antagonists.
PHARMAC’s legislative objective is “to secure for eligible people in need of pharmaceuticals, the best health outcomes that are reasonably achievable from pharmaceutical treatment and from within the amount of funding provided.” Two of the ways in which PHARMAC achieves this is by reference pricing and by negotiating sole supply contracts with pharmaceutical suppliers. When managed appropriatel...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 1985
ISSN: 0306-5251
DOI: 10.1111/j.1365-2125.1985.tb02810.x